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NANOPARTICLES OF PLA/PLGA BIOPOLYMERS PREPARED BY NANO SPRAY DRYING

NANOPARTICLES OF PLA/PLGA BIOPOLYMERS PREPARED BY NANO SPRAY DRYING

Biopolymers based on lactic acid and glycolic acid have attracted great interest in various medical applications. This paper reviews various applications of nano spray drying for the formulation and encapsulation of active ingredients in PLA/PLGA biopolymers. The researched applications are primarily in the therapeutic field, such as the treatment of inhalation diseases, …

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[PDF] Design of PLGA-based depot delivery systems for ...

[PDF] Design of PLGA-based depot delivery systems for ...

Feb 10, 2016 DOI: 10.1016/j.ijpharm.2015.12.025 Corpus ID: 24006975; Design of PLGA-based depot delivery systems for biopharmaceuticals prepared by spray drying. @article{Wan2016DesignOP, title={Design of PLGA-based depot delivery systems for biopharmaceuticals prepared by spray drying.}, author={Feng Wan and Mingshi Yang}, …

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Oral delivery of spray dried PLGA/amifostine nanoparticles

Oral delivery of spray dried PLGA/amifostine nanoparticles

Feb 18, 2010 Two different nanoparticle formulations (Amifostine-PLGA (0.4:1.0 and 1.0:1.0)) were prepared using a Buchi B191 Mini Spray Dryer. A water-in-oil emulsion of amifostine and PLGA (RG 502) was spray dried using an airflow of 600 Lh −1 and input temperature of 55C. A tissue distribution study in mice was conducted following oral administration ...

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One-Step Production of Protein-Loaded PLGA Microparticles via Spray ...

One-Step Production of Protein-Loaded PLGA Microparticles via Spray ...

Feb 19, 2014 In the present study, we introduced a one-step method to prepare protein loaded PLGA microparticles via a spray drying process using a 3-fluid nozzle and investigated the effects of solvent selection and feeding rate on the physicochemical properties of the spray dried microparticles. The spherical microparticles with a condensed internal ...

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Spray drying of siRNA-containing PLGA nanoparticles intended for ...

Spray drying of siRNA-containing PLGA nanoparticles intended for ...

Feb 25, 2010 The nanocomposite microparticles were prepared by spray drying of a PLGA NP suspension in different aqueous carbohydrate solutions using a Bchi B-290 spray dryer (Bchi Labortechnik AG, Postfach, Switzerland). The spray dryer was a co-current model, equipped with a nozzle atomizer using nitrogen as the atomizing gas.

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One-Step Production of Protein-Loaded PLGA Microparticles via Spray ...

One-Step Production of Protein-Loaded PLGA Microparticles via Spray ...

However, microencapsulation of protein drugs using the conventional spray drying technique PLGA (lactide:glycolide molar ratio of 75:25, Mw: 20 kDa, with a 2-fluid nozzle is not optimal due to highly diverse purchased from Wako Pure Chemical Industries, Ltd. (Wako, solvent requirements when dissolving hydrophobic polymers Germany)) was selected ...

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Spray-dried Cefixime Encapsulated Poly(lactide-co-glycolide ...

Spray-dried Cefixime Encapsulated Poly(lactide-co-glycolide ...

May 09, 2012 (2012). Spray-dried Cefixime Encapsulated Poly(lactide-co-glycolide) Microparticles: Characterization and Evaluation of In Vitro Release Kinetics with Antibacterial Activity. Drying Technology: Vol. 30, No. 8, pp. 865-872.

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PLGA sub-micron particles by Nano Spray Drying

PLGA sub-micron particles by Nano Spray Drying

Nano-spray drying for drug delivery of smallest particles. Get your free copy. Aim of this Application Note is to give an application help in spray drying biodegradable polymers such as PLGA using the Nano Spray Dryer B-90 HP combined with the Inert Loop B-295. The use of the Inert Loop B-295 enables to dry solutions or suspensions of organic ...

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Spray-drying preparation of microparticles containing cationic PLGA ...

Spray-drying preparation of microparticles containing cationic PLGA ...

Oct 01, 2007 The PLGA nanosphere emulsion was dried with mannitol by spray-drying, and mannitol microparticles containing PLGA nanospheres were obtained. Mean particle diameter of spray dried PLGA particles was 100–250 nm, which was similar to that of the nano-emulsion before drying, whereas the lyophilized PLGA particles showed increased particle ...

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PLA/PLGA nanoparticles prepared by nano spray drying

PLA/PLGA nanoparticles prepared by nano spray drying

PLA/PLGA nanoparticles prepared by nano spray drying 407 1 3 Table 1 enzyme PublishedstudiesonspraydriedmicroparticlesfromPLAandPLGAbiopolymerswiththeMiniSprayDryerB ...

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Table 3 PLA/PLGA nanoparticles prepared by nano spray drying ...

Table 3 PLA/PLGA nanoparticles prepared by nano spray drying ...

The analyzed studies show the possibility of producing PLGA particles from approx. 2 μm to below 200 nm by nano spray drying, as well as the encapsulation of various active ingredients in spherical particles and nano-in-nanoparticle composite structures made of PLGA polymers for controlled drug delivery systems. ... Spray drying is a ...

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International Journal of Pharmaceutics - Kinam Park

International Journal of Pharmaceutics - Kinam Park

we will focus on the spray drying process to design PLGA-based depot delivery systems for proteins and peptides. Especially, we will discuss the role of nozzle design and solvent properties in the spray drying process, which influence the PLGA microparticle formation process and critical quality attributes of the product. 2.

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